NCAPH [The Human Chemical-Genetic Interaction Map Project]

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======= NCAPH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAPH
  * **<color #00a2e8>Official Name</color>**: non-SMC condensin I complex subunit H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23397|23397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15003|Q15003]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAPH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAPH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cnd2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase (ATP-hydrolyzing) activator activity|
|female meiosis chromosome separation|
|nuclear condensin complex|
|DNA topoisomerase binding|
|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|female meiosis chromosome segregation|
|regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|meiotic chromosome condensation|
|condensin complex|
|regulation of isomerase activity|
|positive regulation of isomerase activity|
|mitotic chromosome condensation|
|meiotic chromosome separation|
|chromosome separation|
|female meiotic nuclear division|
|chromosome condensation|
|positive regulation of ATPase activity|
|chromosome organization involved in meiotic cell cycle|
|regulation of ATPase activity|
|meiotic chromosome segregation|
|mitotic sister chromatid segregation|
|female gamete generation|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|chromatin binding|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|gamete generation|
|positive regulation of hydrolase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|regulation of hydrolase activity|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.29|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.18|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.07|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.92|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.76|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.87|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.93|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.96|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 98/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|2/25|
|breast|6/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|4/21|
|liver|4/20|
|lung|9/75|
|lymphocyte|5/14|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAPH Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>