NCAPH

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aminopterin 0.005μM R07 exp335	-2.29
ONC212 0.15μM R08 exp513	-2.18
Dinaciclib 0.007μM R07 exp355	-2.07
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.05
UM131593 0.2μM R03 exp106	-1.92
CB-5083 0.4μM R08 exp468	-1.76
Quercetin 20μM R08 exp517	1.77
ZLN024 50μM R08 exp538	1.87
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.93
Wortmannin 0.5μM R00 exp37	1.96
Diepoxybutane 3μM R07 exp354	1.99

Global Fraction of Cell Lines Where Essential: 98/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	5/28
bone	2/25
breast	6/33
central nervous system	8/56
cervix	1/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	3/15
kidney	4/21
liver	4/20
lung	9/75
lymphocyte	5/14
ovary	3/26
pancreas	1/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	3/24
soft tissue	2/7
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	0/5

Expression Distribution

DNA topoisomerase (ATP-hydrolyzing) activator activity
female meiosis chromosome separation
nuclear condensin complex
DNA topoisomerase binding
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
female meiosis chromosome segregation
regulation of DNA topoisomerase (ATP-hydrolyzing) activity
meiotic chromosome condensation
condensin complex
regulation of isomerase activity
positive regulation of isomerase activity
mitotic chromosome condensation
meiotic chromosome separation
chromosome separation
female meiotic nuclear division
chromosome condensation
positive regulation of ATPase activity
chromosome organization involved in meiotic cell cycle
regulation of ATPase activity
meiotic chromosome segregation
mitotic sister chromatid segregation
female gamete generation
sister chromatid segregation
mitotic nuclear division
meiotic nuclear division
meiotic cell cycle process
DNA packaging
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
DNA conformation change
organelle fission
cellular process involved in reproduction in multicellular organism
chromatin binding
cell division
mitotic cell cycle process
mitotic cell cycle
gamete generation
positive regulation of hydrolase activity