NCF2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NCF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCF2
  * **<color #00a2e8>Official Name</color>**: neutrophil cytosolic factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4688|4688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19878|P19878]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PB1|
|TPR 1|
|SH3 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagolysosome|
|superoxide-generating NADPH oxidase activator activity|
|superoxide-generating NADPH oxidase activity|
|NADPH oxidase complex|
|superoxide anion generation|
|respiratory burst|
|superoxide metabolic process|
|cellular defense response|
|Rac GTPase binding|
|vascular endothelial growth factor receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|electron transfer activity|
|cell redox homeostasis|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|acrosomal vesicle|
|antigen processing and presentation of peptide antigen via MHC class I|
|reactive oxygen species metabolic process|
|antigen processing and presentation of exogenous peptide antigen|
|electron transport chain|
|antigen processing and presentation of exogenous antigen|
|protein C-terminus binding|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|cellular response to oxidative stress|
|phagocytosis|
|response to oxidative stress|
|generation of precursor metabolites and energy|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|nucleolus|
|cellular homeostasis|
|defense response to other organism|
|oxidation-reduction process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|homeostatic process|
|cellular response to stress|
|positive regulation of molecular function|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCF2 Expression in NALM6 Cells: -0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>