NCF2

Entrez Summary: This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
35°C R06 exp302	1.92
Vinblastine 0.002μM R01 exp60	1.94

phagolysosome
superoxide-generating NADPH oxidase activator activity
superoxide-generating NADPH oxidase activity
NADPH oxidase complex
superoxide anion generation
respiratory burst
superoxide metabolic process
cellular defense response
Rac GTPase binding
vascular endothelial growth factor receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
electron transfer activity
cell redox homeostasis
antigen processing and presentation of exogenous peptide antigen via MHC class I
acrosomal vesicle
antigen processing and presentation of peptide antigen via MHC class I
reactive oxygen species metabolic process
antigen processing and presentation of exogenous peptide antigen
electron transport chain
antigen processing and presentation of exogenous antigen
protein C-terminus binding
antigen processing and presentation of peptide antigen
antigen processing and presentation
cellular response to oxidative stress
phagocytosis
response to oxidative stress
generation of precursor metabolites and energy
transmembrane receptor protein tyrosine kinase signaling pathway
enzyme linked receptor protein signaling pathway
innate immune response
nucleolus
cellular homeostasis
defense response to other organism
oxidation-reduction process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
positive regulation of catalytic activity
homeostatic process