NCKAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCKAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCKAP1
  * **<color #00a2e8>Official Name</color>**: NCK associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10787|10787]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2A7|Q9Y2A7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCKAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCKAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nckap1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|SCAR complex|
|positive regulation of actin nucleation|
|regulation of Arp2/3 complex-mediated actin nucleation|
|positive regulation of lamellipodium assembly|
|Rac protein signal transduction|
|lamellipodium membrane|
|regulation of actin nucleation|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|filamentous actin|
|regulation of lamellipodium organization|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|Rac GTPase binding|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of actin filament polymerization|
|ruffle|
|positive regulation of plasma membrane bounded cell projection assembly|
|positive regulation of protein polymerization|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|small GTPase mediated signal transduction|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|focal adhesion|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|cell projection assembly|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|positive regulation of immune response|
|apoptotic process|
|regulation of cellular component biogenesis|
|cell migration|
|central nervous system development|
|neuron differentiation|
|programmed cell death|
|localization of cell|
|cell motility|
|cell death|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 78/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|0/28|
|bone|2/26|
|breast|2/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|6/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCKAP1 Expression in NALM6 Cells: 3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>