NCKAP1

Gene Information

Official Symbol: NCKAP1
Official Name: NCK associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 10787
UniProt: Q9Y2A7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 78/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	10/28
blood	0/28
bone	2/26
breast	2/33
central nervous system	7/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	6/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	6/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18120
Expression level (log2 read counts): 3.7

Expression Distribution

positive regulation of Arp2/3 complex-mediated actin nucleation
SCAR complex
positive regulation of actin nucleation
regulation of Arp2/3 complex-mediated actin nucleation
positive regulation of lamellipodium assembly
Rac protein signal transduction
lamellipodium membrane
regulation of actin nucleation
positive regulation of lamellipodium organization
regulation of lamellipodium assembly
filamentous actin
regulation of lamellipodium organization
cortical actin cytoskeleton organization
cortical cytoskeleton organization
Rac GTPase binding
vascular endothelial growth factor receptor signaling pathway
positive regulation of actin filament polymerization
ruffle
positive regulation of plasma membrane bounded cell projection assembly
positive regulation of protein polymerization
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
regulation of actin filament polymerization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of cytoskeleton organization
regulation of protein polymerization
Fc receptor signaling pathway
Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
small GTPase mediated signal transduction
phagocytosis
regulation of actin cytoskeleton organization