NCL [The Human Chemical-Genetic Interaction Map Project]

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======= NCL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCL
  * **<color #00a2e8>Official Name</color>**: nucleolin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4691|4691]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19338|P19338]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA topoisomerase binding|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|positive regulation of transcription by RNA polymerase I|
|mRNA 5-UTR binding|
|telomeric DNA binding|
|regulation of transcription by RNA polymerase I|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|cytoplasmic ribonucleoprotein granule|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|negative regulation of translation|
|cell cortex|
|negative regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|protein C-terminus binding|
|angiogenesis|
|regulation of translation|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|tube morphogenesis|
|tube development|
|nucleolus|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.03|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.85|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.8|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.75|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.72|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.8|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.81|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.47|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.461|
|[[:human genes:p:psmb4|PSMB4]]|0.449|
|[[:human genes:n:narfl|NARFL]]|0.443|
|[[:human genes:r:rps2|RPS2]]|0.437|
|[[:human genes:p:ppm1d|PPM1D]]|0.434|
|[[:human genes:p:paf1|PAF1]]|0.432|
|[[:human genes:o:orc6|ORC6]]|0.431|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.43|
|[[:human genes:n:nol7|NOL7]]|0.426|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.421|
|[[:human genes:u:utp3|UTP3]]|0.417|
|[[:human genes:p:psma6|PSMA6]]|0.417|
|[[:human genes:r:rpl6|RPL6]]|0.411|
|[[:human genes:i:isy1|ISY1]]|0.41|
|[[:human genes:r:rps19|RPS19]]|0.41|
|[[:human genes:r:rrp7a|RRP7A]]|0.408|
|[[:human genes:d:dimt1|DIMT1]]|0.405|
|[[:human genes:s:sf3a3|SF3A3]]|0.403|
|[[:human genes:b:bms1|BMS1]]|0.403|
|[[:human genes:c:cactin|CACTIN]]|0.401|
|[[:human genes:c:ctage4|CTAGE4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 99/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|10/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1855
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCL Expression in NALM6 Cells: 10.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>