NCL

Entrez Summary: N/A
UniProt Summary: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 99/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	0/28
bone	0/26
breast	4/33
central nervous system	14/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	1/1
gastric	2/16
kidney	10/21
liver	1/20
lung	5/75
lymphocyte	3/16
ovary	5/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	10/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	0/5

Expression Distribution

DNA topoisomerase binding
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
regulation of transcription of nucleolar large rRNA by RNA polymerase I
positive regulation of transcription by RNA polymerase I
mRNA 5-UTR binding
telomeric DNA binding
regulation of transcription by RNA polymerase I
cellular response to epidermal growth factor stimulus
response to epidermal growth factor
cytoplasmic ribonucleoprotein granule
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
negative regulation of translation
cell cortex
negative regulation of cellular amide metabolic process
ribonucleoprotein complex
protein C-terminus binding
angiogenesis
regulation of translation
regulation of cellular amide metabolic process
blood vessel morphogenesis
blood vessel development
cellular response to growth factor stimulus
vasculature development
cardiovascular system development
posttranscriptional regulation of gene expression
response to growth factor
tube morphogenesis
tube development
nucleolus
circulatory system development
anatomical structure formation involved in morphogenesis
cellular response to cytokine stimulus
negative regulation of cellular protein metabolic process
identical protein binding
response to cytokine
negative regulation of protein metabolic process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
negative regulation of cellular macromolecule biosynthetic process