NCOR2 [The Human Chemical-Genetic Interaction Map Project]

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======= NCOR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCOR2
  * **<color #00a2e8>Official Name</color>**: nuclear receptor corepressor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9612|9612]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y618|Q9Y618]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCOR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCOR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:23911289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter|
|regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter|
|negative regulation of production of miRNAs involved in gene silencing by miRNA|
|RNA polymerase II regulatory region DNA binding|
|negative regulation of gene silencing by miRNA|
|negative regulation of androgen receptor signaling pathway|
|negative regulation of posttranscriptional gene silencing|
|glucocorticoid receptor binding|
|negative regulation of gene silencing by RNA|
|retinoid X receptor binding|
|estrous cycle|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|nuclear hormone receptor binding|
|regulation of androgen receptor signaling pathway|
|Notch binding|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|histone deacetylase complex|
|negative regulation of gene silencing|
|lactation|
|transcriptional repressor complex|
|ovulation cycle|
|body fluid secretion|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein N-terminus binding|
|nuclear matrix|
|histone deacetylase binding|
|mammary gland development|
|regulation of gene silencing|
|response to estradiol|
|regulation of cellular ketone metabolic process|
|nuclear chromatin|
|transcription corepressor activity|
|protein-containing complex binding|
|rhythmic process|
|nuclear body|
|chromatin binding|
|regulation of lipid metabolic process|
|gland development|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|regulation of body fluid levels|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to nitrogen compound|
|secretion|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.04|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.86|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.88|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.06|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2346
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCOR2 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>