NCOR2

Gene Information

Official Symbol: NCOR2
Official Name: nuclear receptor corepressor 2
Aliases and Previous Symbols: N/A
Entrez ID: 9612
UniProt: Q9Y618
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011].
UniProt Summary: Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:23911289}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.04
BI-6727 0.001μM R01 exp42	1.81
Dexamethasone 0.006μM R07 exp351	1.86
Vinblastine 0.002μM R01 exp60	1.88
Rifampicin 10μM R00 exp32	2.06
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.07

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2346
Expression level (log2 read counts): 7.68

Expression Distribution

regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
negative regulation of production of miRNAs involved in gene silencing by miRNA
RNA polymerase II regulatory region DNA binding
negative regulation of gene silencing by miRNA
negative regulation of androgen receptor signaling pathway
negative regulation of posttranscriptional gene silencing
glucocorticoid receptor binding
negative regulation of gene silencing by RNA
retinoid X receptor binding
estrous cycle
regulation of production of miRNAs involved in gene silencing by miRNA
regulation of production of small RNA involved in gene silencing by RNA
nuclear hormone receptor binding
regulation of androgen receptor signaling pathway
Notch binding
negative regulation of intracellular steroid hormone receptor signaling pathway
histone deacetylase complex
negative regulation of gene silencing
lactation
transcriptional repressor complex
ovulation cycle
body fluid secretion
regulation of intracellular steroid hormone receptor signaling pathway
regulation of gene silencing by miRNA
regulation of posttranscriptional gene silencing
regulation of gene silencing by RNA
protein N-terminus binding
nuclear matrix
histone deacetylase binding
mammary gland development
regulation of gene silencing
response to estradiol
regulation of cellular ketone metabolic process
nuclear chromatin
transcription corepressor activity
protein-containing complex binding
rhythmic process
nuclear body
chromatin binding