NCR3

Gene Information

Official Symbol: NCR3
Official Name: natural cytotoxicity triggering receptor 3
Aliases and Previous Symbols: N/A
Entrez ID: 259197
UniProt: O14931
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.11
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.71
Deferoxamine 11μM R07 exp350	1.75
Rapamycin 2μM R07 exp306	1.77
UMK57 1μM R01 exp59	1.89
Vinblastine 0.002μM R01 exp60	2.64

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6258
Expression level (log2 read counts): -6.6

Expression Distribution

positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
positive regulation of immune effector process
cell recognition
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
inflammatory response
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
leukocyte activation
identical protein binding
cell activation
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
defense response