NDN

Entrez Summary: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008].
UniProt Summary: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

respiratory system process
neurotrophin TRK receptor signaling pathway
neuron projection fasciculation
axonal fasciculation
genetic imprinting
gamma-tubulin binding
neurotrophin signaling pathway
axon extension
glial cell migration
respiratory gaseous exchange by respiratory system
neuron recognition
neuron projection extension
sensory perception of pain
developmental cell growth
post-embryonic development
cell growth
cell projection
developmental growth involved in morphogenesis
neuron migration
perikaryon
gliogenesis
cell recognition
multicellular organismal homeostasis
axonogenesis
developmental growth
growth
axon development
cell morphogenesis involved in neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
centrosome
cellular response to growth factor stimulus
RNA polymerase II proximal promoter sequence-specific DNA binding
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
response to growth factor
cell morphogenesis involved in differentiation
neuron projection development