NDST2

Entrez Summary: This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009].
UniProt Summary: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444, ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LLY-284 2.6μM R06 exp291	1.9
Doxycycline 10μM R00 exp18	2.19

HSNSD
Sulfotransfer 1

[heparan sulfate]-glucosamine N-sulfotransferase activity
heparan sulfate N-acetylglucosaminyltransferase activity
heparin biosynthetic process
heparin metabolic process
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
heparan sulfate sulfotransferase activity
deacetylase activity
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
sulfur compound biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process