NDUFA9 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA9
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4704|4704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16795|Q16795]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:22114105, ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NmrA|
|Epimerase|
|3Beta HSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquinone-6 biosynthetic process|
|ubiquinone-6 metabolic process|
|NADH dehydrogenase activity|
|coenzyme binding|
|ubiquinone biosynthetic process|
|quinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|quinone metabolic process|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|oxidoreduction coenzyme metabolic process|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|cellular ketone metabolic process|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|oxidative phosphorylation|
|coenzyme biosynthetic process|
|response to glucose|
|circadian rhythm|
|response to hexose|
|response to monosaccharide|
|sodium ion transport|
|cellular respiration|
|response to carbohydrate|
|electron transport chain|
|ATP metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|coenzyme metabolic process|
|protein-containing complex binding|
|rhythmic process|
|mitochondrial matrix|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|mitochondrion organization|
|small molecule biosynthetic process|
|metal ion transport|
|cation transport|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|ion transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.75|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.87|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.92|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.15|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.45|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa13|NDUFA13]]|0.533|
|[[:human genes:n:ndufa1|NDUFA1]]|0.533|
|[[:human genes:n:nubpl|NUBPL]]|0.531|
|[[:human genes:m:mto1|MTO1]]|0.49|
|[[:human genes:n:ndufb10|NDUFB10]]|0.488|
|[[:human genes:a:acad9|ACAD9]]|0.487|
|[[:human genes:n:ndufb7|NDUFB7]]|0.479|
|[[:human genes:n:ndufb11|NDUFB11]]|0.469|
|[[:human genes:n:ndufc2|NDUFC2]]|0.469|
|[[:human genes:n:ndufs2|NDUFS2]]|0.468|
|[[:human genes:n:ndufa8|NDUFA8]]|0.467|
|[[:human genes:g:grsf1|GRSF1]]|0.46|
|[[:human genes:n:ndufa2|NDUFA2]]|0.46|
|[[:human genes:n:ndufa11|NDUFA11]]|0.451|
|[[:human genes:n:ndufb4|NDUFB4]]|0.45|
|[[:human genes:n:ndufs8|NDUFS8]]|0.445|
|[[:human genes:n:ndufb8|NDUFB8]]|0.443|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.441|
|[[:human genes:n:ndufv2|NDUFV2]]|0.438|
|[[:human genes:n:ndufb9|NDUFB9]]|0.436|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.431|
|[[:human genes:n:ndufa6|NDUFA6]]|0.429|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.424|
|[[:human genes:m:mtif2|MTIF2]]|0.418|
|[[:human genes:p:pde12|PDE12]]|0.408|
|[[:human genes:n:ndufa3|NDUFA3]]|0.408|
|[[:human genes:s:slc25a51|SLC25A51]]|0.405|
|[[:human genes:n:ndufc1|NDUFC1]]|0.405|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.404|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.403|
|[[:human genes:f:foxred1|FOXRED1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 894
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA9 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>