NDUFA9

Entrez Summary: The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:22114105, ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquinone-6 biosynthetic process
ubiquinone-6 metabolic process
NADH dehydrogenase activity
coenzyme binding
ubiquinone biosynthetic process
quinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
quinone metabolic process
NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
oxidoreduction coenzyme metabolic process
mitochondrial respiratory chain complex I
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
cellular ketone metabolic process
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
mitochondrial membrane
respiratory electron transport chain
oxidative phosphorylation
coenzyme biosynthetic process
response to glucose
circadian rhythm
response to hexose
response to monosaccharide
sodium ion transport
cellular respiration
response to carbohydrate
electron transport chain
ATP metabolic process
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
coenzyme metabolic process
protein-containing complex binding
rhythmic process
mitochondrial matrix
monovalent inorganic cation transport
generation of precursor metabolites and energy