NDUFB7 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB7
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4713|4713]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17568|P17568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603842|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial intermembrane space|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.78|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.72|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.73|
|[[:results:exp302|35°C R06 exp302]]|1.74|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.74|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.74|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.89|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.9|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.97|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.06|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.06|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.16|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.17|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.18|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.18|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.25|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.26|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.36|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.38|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.4|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.71|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.03|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb9|NDUFB9]]|0.674|
|[[:human genes:n:ndufs2|NDUFS2]]|0.636|
|[[:human genes:n:ndufa1|NDUFA1]]|0.629|
|[[:human genes:a:acad9|ACAD9]]|0.62|
|[[:human genes:g:grsf1|GRSF1]]|0.615|
|[[:human genes:n:ndufc2|NDUFC2]]|0.615|
|[[:human genes:m:mto1|MTO1]]|0.598|
|[[:human genes:n:ndufa2|NDUFA2]]|0.593|
|[[:human genes:n:ndufb11|NDUFB11]]|0.59|
|[[:human genes:n:ndufa11|NDUFA11]]|0.589|
|[[:human genes:n:nubpl|NUBPL]]|0.586|
|[[:human genes:n:ndufa3|NDUFA3]]|0.583|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.581|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.58|
|[[:human genes:n:ndufs8|NDUFS8]]|0.573|
|[[:human genes:n:ndufv1|NDUFV1]]|0.569|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.541|
|[[:human genes:c:chchd1|CHCHD1]]|0.537|
|[[:human genes:n:ndufb10|NDUFB10]]|0.537|
|[[:human genes:n:ndufs7|NDUFS7]]|0.536|
|[[:human genes:n:ndufc1|NDUFC1]]|0.535|
|[[:human genes:n:ndufb4|NDUFB4]]|0.525|
|[[:human genes:e:ecsit|ECSIT]]|0.525|
|[[:human genes:n:ndufa8|NDUFA8]]|0.525|
|[[:human genes:n:ndufs5|NDUFS5]]|0.518|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.508|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.505|
|[[:human genes:n:ndufs1|NDUFS1]]|0.501|
|[[:human genes:n:ndufa13|NDUFA13]]|0.5|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.5|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.499|
|[[:human genes:f:foxred1|FOXRED1]]|0.495|
|[[:human genes:n:ndufb6|NDUFB6]]|0.495|
|[[:human genes:n:ndufs3|NDUFS3]]|0.495|
|[[:human genes:n:ndufv2|NDUFV2]]|0.488|
|[[:human genes:n:ndufa10|NDUFA10]]|0.486|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.485|
|[[:human genes:c:coq7|COQ7]]|0.484|
|[[:human genes:n:ndufa6|NDUFA6]]|0.484|
|[[:human genes:m:mtif2|MTIF2]]|0.483|
|[[:human genes:n:ndufb8|NDUFB8]]|0.482|
|[[:human genes:p:pde12|PDE12]]|0.48|
|[[:human genes:n:ndufa9|NDUFA9]]|0.479|
|[[:human genes:f:fastkd2|FASTKD2]]|0.478|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.477|
|[[:human genes:s:ssbp1|SSBP1]]|0.475|
|[[:human genes:m:mrpl13|MRPL13]]|0.474|
|[[:human genes:m:mrps25|MRPS25]]|0.47|
|[[:human genes:a:atp5sl|ATP5SL]]|0.47|
|[[:human genes:m:mrp63|MRP63]]|0.468|
|[[:human genes:f:ftsj2|FTSJ2]]|0.467|
|[[:human genes:m:mrps21|MRPS21]]|0.463|
|[[:human genes:r:rpusd3|RPUSD3]]|0.462|
|[[:human genes:t:tmem261|TMEM261]]|0.46|
|[[:human genes:n:ndufa5|NDUFA5]]|0.46|
|[[:human genes:i:ict1|ICT1]]|0.456|
|[[:human genes:m:mettl17|METTL17]]|0.456|
|[[:human genes:m:mtg1|MTG1]]|0.451|
|[[:human genes:g:gfm2|GFM2]]|0.447|
|[[:human genes:m:mrpl45|MRPL45]]|0.447|
|[[:human genes:n:ndufb5|NDUFB5]]|0.447|
|[[:human genes:a:aars2|AARS2]]|0.44|
|[[:human genes:n:ndufb2|NDUFB2]]|0.44|
|[[:human genes:c:coq2|COQ2]]|0.439|
|[[:human genes:q:qrsl1|QRSL1]]|0.438|
|[[:human genes:g:glrx5|GLRX5]]|0.437|
|[[:human genes:n:noa1|NOA1]]|0.436|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.435|
|[[:human genes:e:eral1|ERAL1]]|0.43|
|[[:human genes:n:nsun4|NSUN4]]|0.429|
|[[:human genes:m:mrpl3|MRPL3]]|0.429|
|[[:human genes:s:slc25a51|SLC25A51]]|0.428|
|[[:human genes:m:mtg2|MTG2]]|0.427|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.425|
|[[:human genes:s:sfxn4|SFXN4]]|0.424|
|[[:human genes:p:polg2|POLG2]]|0.422|
|[[:human genes:c:c12orf65|C12orf65]]|0.421|
|[[:human genes:p:pet112|PET112]]|0.418|
|[[:human genes:i:iba57|IBA57]]|0.418|
|[[:human genes:c:c1qbp|C1QBP]]|0.414|
|[[:human genes:t:tfb1m|TFB1M]]|0.413|
|[[:human genes:m:mcat|MCAT]]|0.412|
|[[:human genes:c:cars2|CARS2]]|0.408|
|[[:human genes:l:lars2|LARS2]]|0.406|
|[[:human genes:c:c17orf89|C17orf89]]|0.405|
|[[:human genes:m:mrps5|MRPS5]]|0.405|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.405|
|[[:human genes:s:slc25a52|SLC25A52]]|0.404|
|[[:human genes:d:dap3|DAP3]]|0.404|
|[[:human genes:p:polrmt|POLRMT]]|0.404|
|[[:human genes:w:wbscr16|WBSCR16]]|0.403|
|[[:human genes:m:mrpl21|MRPL21]]|0.403|
|[[:human genes:n:nars2|NARS2]]|0.402|
|[[:human genes:p:pdss1|PDSS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 395
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB7 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>