NDUFB7

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.015μM R05 exp208	-1.78
Hydroxyurea 100μM R07 exp329	1.71
iCRT14 30μM R08 exp492	1.72
LLY-283 2.6μM R06 exp290	1.72
Dimethyloxaloylglycine 100μM R05 exp229	1.73
35°C R06 exp302	1.74
Apcin 25μM plus proTAME 2μM R04 exp177	1.74
GW501516 25μM R06 exp285	1.74
Rucaparib 6.5μM R08 exp520	1.89
GSK-J4 1.5μM R08 exp441	1.9
GSK-J4 1μM R07 exp362	1.97
Campthothecin 0.001μM R06 exp270	2.06
Ribavirin 10 to 15μM on day4 R04 exp160	2.06
Mubritinib 0.2μM R01 exp48	2.16
Vemurafenib 6.6μM R08 exp434	2.17
Aphidicolin 0.4μM R08 exp440	2.18
Tubacin 1.6μM R07 exp416	2.18
Curcumin 6.5μM R06 exp277	2.25
Pyronaridine 1μM R06 exp295	2.26
Genistein 15μM R07 exp360	2.36
VER-155008 3.9μM R06 exp301	2.38
Atovaquone 15μM R08 exp451	2.4
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.71
Artemisinin 50μM R08 exp450	2.99
Oligomycin-A 2μM R00 exp25	3.03
HMS-I2 10μM R06 exp288	3.67

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	6/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	1/5

Expression Distribution

NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
mitochondrial intermembrane space
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
mitochondrion
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization