NEBL

Entrez Summary: This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
UniProt Summary: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cardiac muscle thin filament assembly
filamin binding
tropomyosin binding
I band
cardiac myofibril assembly
structural constituent of muscle
muscle fiber development
cardiac muscle cell development
cardiac cell development
myofibril assembly
stress fiber
cytoskeletal protein binding
cardiac muscle cell differentiation
cellular component assembly involved in morphogenesis
actomyosin structure organization
cardiocyte differentiation
Z disc
striated muscle cell development
muscle cell development
cardiac muscle tissue development
striated muscle cell differentiation
actin filament binding
actin filament organization
muscle cell differentiation
striated muscle tissue development
muscle tissue development
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
heart development
actin filament-based process
organelle assembly
cellular component morphogenesis
circulatory system development
anatomical structure formation involved in morphogenesis
cytoskeleton organization
cell development
tissue development