NECAB2

Gene Information

Official Symbol: NECAB2
Official Name: N-terminal EF-hand calcium binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 54550
UniProt: Q7Z6G3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4142
Expression level (log2 read counts): -7.68

Expression Distribution

A2A adenosine receptor binding
negative regulation of G protein-coupled receptor internalization
positive regulation of adenosine receptor signaling pathway
regulation of G protein-coupled receptor internalization
regulation of adenosine receptor signaling pathway
type 5 metabotropic glutamate receptor binding
negative regulation of receptor internalization
regulation of amyloid precursor protein biosynthetic process
positive regulation of glutamate receptor signaling pathway
negative regulation of receptor-mediated endocytosis
positive regulation of G protein-coupled receptor signaling pathway
regulation of glycoprotein biosynthetic process
negative regulation of endocytosis
regulation of glycoprotein metabolic process
regulation of receptor internalization
regulation of glutamate receptor signaling pathway
regulation of receptor-mediated endocytosis
positive regulation of protein localization to membrane
regulation of G protein-coupled receptor signaling pathway
regulation of protein localization to membrane
regulation of endocytosis
positive regulation of ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade
axon
positive regulation of cellular protein localization
dendrite
negative regulation of transport
regulation of cellular protein localization
positive regulation of MAPK cascade
regulation of vesicle-mediated transport
negative regulation of cellular component organization
calcium ion binding
regulation of MAPK cascade
regulation of cellular localization
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
regulation of protein localization
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process