NEDD9 [The Human Chemical-Genetic Interaction Map Project]

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======= NEDD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEDD9
  * **<color #00a2e8>Official Name</color>**: neural precursor cell expressed, developmentally down-regulated 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4739|4739]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14511|Q14511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEDD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEDD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serine rich|
|SH3 1|
|SH3 2|
|DUF3513|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament reorganization|
|protein tyrosine kinase binding|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of protein tyrosine kinase activity|
|actin filament bundle assembly|
|actin cytoskeleton reorganization|
|actin filament bundle organization|
|regulation of protein tyrosine kinase activity|
|integrin-mediated signaling pathway|
|activation of GTPase activity|
|spindle|
|positive regulation of cell-substrate adhesion|
|spindle pole|
|cell cortex|
|positive regulation of cell morphogenesis involved in differentiation|
|lamellipodium|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of cell-substrate adhesion|
|actin filament organization|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|focal adhesion|
|supramolecular fiber organization|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|actin filament-based process|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of growth|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13701
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEDD9 Expression in NALM6 Cells: 3.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>