NEDD9

Official Symbol: NEDD9
Official Name: neural precursor cell expressed, developmentally down-regulated 9
Aliases and Previous Symbols: N/A
Entrez ID: 4739
UniProt: Q14511
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin filament reorganization
protein tyrosine kinase binding
positive regulation of substrate adhesion-dependent cell spreading
regulation of substrate adhesion-dependent cell spreading
positive regulation of protein tyrosine kinase activity
actin filament bundle assembly
actin cytoskeleton reorganization
actin filament bundle organization
regulation of protein tyrosine kinase activity
integrin-mediated signaling pathway
activation of GTPase activity
spindle
positive regulation of cell-substrate adhesion
spindle pole
cell cortex
positive regulation of cell morphogenesis involved in differentiation
lamellipodium
positive regulation of peptidyl-tyrosine phosphorylation
regulation of cell-substrate adhesion
actin filament organization
regulation of peptidyl-tyrosine phosphorylation
regulation of cell morphogenesis involved in differentiation
positive regulation of cell adhesion
positive regulation of GTPase activity
focal adhesion
supramolecular fiber organization
regulation of GTPase activity
regulation of cell morphogenesis
cell division
actin cytoskeleton organization
positive regulation of cell migration
positive regulation of cell motility
positive regulation of protein kinase activity
positive regulation of cellular component movement
positive regulation of cell development
positive regulation of locomotion
actin filament-based process
positive regulation of kinase activity
positive regulation of transferase activity
regulation of growth