NEK6 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NEK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEK6
  * **<color #00a2e8>Official Name</color>**: NIMA related kinase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10783|10783]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC98|Q9HC98]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604884|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20407017, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic nuclear envelope disassembly|
|transcription corepressor binding|
|nuclear envelope disassembly|
|membrane disassembly|
|activating transcription factor binding|
|regulation of cellular senescence|
|kinesin binding|
|regulation of cell aging|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|nuclear envelope organization|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|spindle assembly|
|regulation of chromosome segregation|
|spindle pole|
|nucleus organization|
|spindle organization|
|microtubule organizing center|
|regulation of mitotic nuclear division|
|peptidyl-serine phosphorylation|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of nuclear division|
|protein autophosphorylation|
|peptidyl-serine modification|
|magnesium ion binding|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|chromosome segregation|
|ubiquitin protein ligase binding|
|microtubule|
|regulation of chromosome organization|
|protein serine/threonine kinase activity|
|cellular component disassembly|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|regulation of cell cycle phase transition|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|organelle assembly|
|membrane organization|
|peptidyl-amino acid modification|
|apoptotic process|
|protein phosphorylation|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|regulation of cell cycle|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|regulation of response to stress|
|ATP binding|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.99|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.81|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.7|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14058
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEK6 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>