NEK6

Entrez Summary: N/A
UniProt Summary: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20407017, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

mitotic nuclear envelope disassembly
transcription corepressor binding
nuclear envelope disassembly
membrane disassembly
activating transcription factor binding
regulation of cellular senescence
kinesin binding
regulation of cell aging
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
nuclear envelope organization
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
spindle assembly
regulation of chromosome segregation
spindle pole
nucleus organization
spindle organization
microtubule organizing center
regulation of mitotic nuclear division
peptidyl-serine phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of nuclear division
protein autophosphorylation
peptidyl-serine modification
magnesium ion binding
regulation of I-kappaB kinase/NF-kappaB signaling
chromosome segregation
ubiquitin protein ligase binding
microtubule
regulation of chromosome organization
protein serine/threonine kinase activity
cellular component disassembly
nuclear speck
regulation of mitotic cell cycle phase transition
endomembrane system organization
regulation of cell cycle phase transition
protein kinase binding