NEK7

Entrez Summary: N/A
UniProt Summary: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. {ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

positive regulation of telomere capping
regulation of telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance
regulation of telomerase activity
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
regulation of telomere maintenance
spindle assembly
regulation of DNA biosynthetic process
spindle pole
spindle organization
microtubule organizing center
positive regulation of chromosome organization
positive regulation of DNA metabolic process
microtubule
regulation of chromosome organization
regulation of DNA metabolic process
protein serine/threonine kinase activity
microtubule cytoskeleton organization
positive regulation of organelle organization
regulation of mitotic cell cycle
positive regulation of transferase activity
microtubule-based process
organelle assembly
protein phosphorylation
regulation of transferase activity
cell cycle process
cytoskeleton organization
regulation of cell cycle
positive regulation of cellular component organization
phosphorylation
regulation of organelle organization
cell cycle
positive regulation of catalytic activity
ATP binding
positive regulation of molecular function