NES [The Human Chemical-Genetic Interaction Map Project]

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======= NES =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NES
  * **<color #00a2e8>Official Name</color>**: nestin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10763|10763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48681|P48681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NES&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NES|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of intermediate filament depolymerization|
|regulation of intermediate filament polymerization or depolymerization|
|positive regulation of intermediate filament depolymerization|
|intermediate filament binding|
|positive regulation of protein depolymerization|
|embryonic camera-type eye development|
|positive regulation of protein complex disassembly|
|intermediate filament cytoskeleton|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|regulation of protein depolymerization|
|regulation of neural precursor cell proliferation|
|negative regulation of protein binding|
|regulation of protein complex disassembly|
|intermediate filament|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|negative regulation of neuron apoptotic process|
|negative regulation of binding|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|regulation of neuron death|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|regulation of binding|
|embryonic organ development|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of cytoskeleton organization|
|sensory organ development|
|cell population proliferation|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|mitotic cell cycle|
|cell morphogenesis|
|brain development|
|molecular function|
|head development|
|negative regulation of catalytic activity|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7345
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NES Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>