NES

Entrez Summary: This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011].
UniProt Summary: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of intermediate filament depolymerization
regulation of intermediate filament polymerization or depolymerization
positive regulation of intermediate filament depolymerization
intermediate filament binding
positive regulation of protein depolymerization
embryonic camera-type eye development
positive regulation of protein complex disassembly
intermediate filament cytoskeleton
positive regulation of neural precursor cell proliferation
stem cell proliferation
regulation of protein depolymerization
regulation of neural precursor cell proliferation
negative regulation of protein binding
regulation of protein complex disassembly
intermediate filament
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
negative regulation of neuron apoptotic process
negative regulation of binding
negative regulation of neuron death
regulation of neuron apoptotic process
regulation of protein binding
positive regulation of cytoskeleton organization
mitotic cell cycle phase transition
cell cycle phase transition
regulation of neuron death
camera-type eye development
eye development
visual system development
sensory system development
regulation of binding
embryonic organ development
cell projection morphogenesis
cell part morphogenesis
regulation of cytoskeleton organization
sensory organ development
cell population proliferation
mitotic cell cycle process
positive regulation of organelle organization
mitotic cell cycle