NETO1

Entrez Summary: N/A
UniProt Summary: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ldl recept a
CUB

regulation of kainate selective glutamate receptor activity
postsynaptic density membrane
regulation of long-term neuronal synaptic plasticity
positive regulation of excitatory postsynaptic potential
excitatory synapse
ionotropic glutamate receptor binding
modulation of excitatory postsynaptic potential
receptor localization to synapse
visual learning
integral component of postsynaptic density membrane
regulation of neuronal synaptic plasticity
visual behavior
regulation of sodium ion transmembrane transporter activity
regulation of potassium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
positive regulation of nervous system process
protein localization to synapse
regulation of glutamate receptor signaling pathway
regulation of neurotransmitter receptor activity
associative learning
regulation of potassium ion transmembrane transport
regulation of sodium ion transport
regulation of potassium ion transport
memory
regulation of nervous system process
learning
positive regulation of synaptic transmission
regulation of cation channel activity
regulation of signaling receptor activity
regulation of synaptic plasticity
postsynaptic density
protein-containing complex localization
regulation of ion transmembrane transporter activity
learning or memory
regulation of transmembrane transporter activity
regulation of transporter activity
cognition
response to light stimulus
regulation of cation transmembrane transport
glutamatergic synapse