NEU2

Entrez Summary: N/A
UniProt Summary: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides. {ECO:0000269|PubMed:14613940, ECO:0000269|PubMed:22228546}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular oligosaccharide catabolic process
cellular oligosaccharide metabolic process
exo-alpha-(2→3)-sialidase activity
exo-alpha-(2→8)-sialidase activity
exo-alpha-(2→6)-sialidase activity
exo-alpha-sialidase activity
ganglioside catabolic process
catalytic complex
glycosphingolipid catabolic process
oligosaccharide catabolic process
glycolipid catabolic process
ganglioside metabolic process
ceramide catabolic process
sphingolipid catabolic process
membrane lipid catabolic process
cellular carbohydrate catabolic process
oligosaccharide metabolic process
glycosphingolipid metabolic process
ceramide metabolic process
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate catabolic process
sphingolipid metabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lipid catabolic process
carbohydrate metabolic process
intracellular membrane-bounded organelle
cellular amide metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process
membrane