NFASC [The Human Chemical-Genetic Interaction Map Project]

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======= NFASC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFASC
  * **<color #00a2e8>Official Name</color>**: neurofascin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23114|23114]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94856|O94856]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFASC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFASC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|fn3|
|V-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Schwann cell microvillus|
|protein localization to juxtaparanode region of axon|
|protein localization to paranode region of axon|
|clustering of voltage-gated sodium channels|
|paranodal junction assembly|
|protein binding involved in heterotypic cell-cell adhesion|
|paranodal junction|
|protein localization to axon|
|neuronal ion channel clustering|
|paranode region of axon|
|node of Ranvier|
|myelin assembly|
|axon initial segment|
|heterotypic cell-cell adhesion|
|neuron maturation|
|transmission of nerve impulse|
|ficolin-1-rich granule membrane|
|peripheral nervous system development|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|anatomical structure maturation|
|multicellular organismal signaling|
|cell-cell junction organization|
|cell maturation|
|cell junction assembly|
|protein localization to plasma membrane|
|cell junction organization|
|protein localization to cell periphery|
|developmental maturation|
|protein domain specific binding|
|axon guidance|
|neuron projection guidance|
|synapse organization|
|axonogenesis|
|axon development|
|focal adhesion|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|neuron projection development|
|regulated exocytosis|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell activation|
|immune effector process|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|locomotion|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFASC Expression in NALM6 Cells: 2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>