NFASC

Entrez Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Schwann cell microvillus
protein localization to juxtaparanode region of axon
protein localization to paranode region of axon
clustering of voltage-gated sodium channels
paranodal junction assembly
protein binding involved in heterotypic cell-cell adhesion
paranodal junction
protein localization to axon
neuronal ion channel clustering
paranode region of axon
node of Ranvier
myelin assembly
axon initial segment
heterotypic cell-cell adhesion
neuron maturation
transmission of nerve impulse
ficolin-1-rich granule membrane
peripheral nervous system development
cellular component assembly involved in morphogenesis
cell-cell junction assembly
myelination
axon ensheathment
ensheathment of neurons
anatomical structure maturation
multicellular organismal signaling
cell-cell junction organization
cell maturation
cell junction assembly
protein localization to plasma membrane
cell junction organization
protein localization to cell periphery
developmental maturation
protein domain specific binding
axon guidance
neuron projection guidance
synapse organization
axonogenesis
axon development
focal adhesion
dendrite