NFE2

Entrez Summary: N/A
UniProt Summary: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chromatin disassembly
nucleosome disassembly
protein-DNA complex disassembly
WW domain binding
proximal promoter sequence-specific DNA binding
protein-DNA complex
regulation of megakaryocyte differentiation
transcription regulatory region sequence-specific DNA binding
PML body
protein N-terminus binding
chromatin assembly or disassembly
nucleosome organization
regulation of myeloid cell differentiation
protein-containing complex disassembly
protein-DNA complex subunit organization
transcription coactivator activity
blood coagulation
coagulation
hemostasis
blood circulation
circulatory system process
cellular component disassembly
sequence-specific DNA binding
regulation of hemopoiesis
wound healing
regulation of body fluid levels
response to wounding
DNA-binding transcription factor activity
chromatin organization
chromosome organization
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
positive regulation of RNA metabolic process
regulation of cell differentiation
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process