NFIB [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NFIB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFIB
  * **<color #00a2e8>Official Name</color>**: nuclear factor I B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4781|4781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00712|O00712]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFIB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFIB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600728|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NfI DNAbd pre-N|
|CTF NFI|
|MH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of epithelial cell proliferation involved in lung morphogenesis|
|lung ciliated cell differentiation|
|negative regulation of mesenchymal cell proliferation involved in lung development|
|principal sensory nucleus of trigeminal nerve development|
|trigeminal sensory nucleus development|
|regulation of mesenchymal cell proliferation involved in lung development|
|cell differentiation involved in salivary gland development|
|Clara cell differentiation|
|salivary gland cavitation|
|type I pneumocyte differentiation|
|type II pneumocyte differentiation|
|tube lumen cavitation|
|anterior commissure morphogenesis|
|cerebellar mossy fiber|
|regulation of epithelial cell proliferation involved in lung morphogenesis|
|negative regulation of mesenchymal cell proliferation|
|lung secretory cell differentiation|
|commissural neuron axon guidance|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|lung epithelial cell differentiation|
|lung cell differentiation|
|central nervous system projection neuron axonogenesis|
|salivary gland morphogenesis|
|lung epithelium development|
|salivary gland development|
|regulation of mesenchymal cell proliferation|
|negative regulation of animal organ morphogenesis|
|central nervous system neuron axonogenesis|
|regulation of pri-miRNA transcription by RNA polymerase II|
|exocrine system development|
|neural nucleus development|
|central nervous system neuron development|
|chondrocyte differentiation|
|gland morphogenesis|
|negative regulation of epithelial cell proliferation|
|fibrillar center|
|tube formation|
|hindbrain development|
|lung development|
|glial cell differentiation|
|cartilage development|
|respiratory tube development|
|central nervous system neuron differentiation|
|respiratory system development|
|DNA replication|
|gliogenesis|
|connective tissue development|
|regulation of animal organ morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|regulation of epithelial cell proliferation|
|axonogenesis|
|forebrain development|
|axon development|
|gland development|
|cell morphogenesis involved in neuron differentiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tube morphogenesis|
|neuron projection development|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|response to bacterium|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.95|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.89|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.75|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.72|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.71|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFIB Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>