NFIB
Gene Information
- Official Symbol: NFIB
- Official Name: nuclear factor I B
- Aliases and Previous Symbols: N/A
- Entrez ID: 4781
- UniProt: O00712
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| NfI DNAbd pre-N |
| CTF NFI |
| MH1 |
GO Terms
| negative regulation of epithelial cell proliferation involved in lung morphogenesis |
| lung ciliated cell differentiation |
| negative regulation of mesenchymal cell proliferation involved in lung development |
| principal sensory nucleus of trigeminal nerve development |
| trigeminal sensory nucleus development |
| regulation of mesenchymal cell proliferation involved in lung development |
| cell differentiation involved in salivary gland development |
| Clara cell differentiation |
| salivary gland cavitation |
| type I pneumocyte differentiation |
| type II pneumocyte differentiation |
| tube lumen cavitation |
| anterior commissure morphogenesis |
| cerebellar mossy fiber |
| regulation of epithelial cell proliferation involved in lung morphogenesis |
| negative regulation of mesenchymal cell proliferation |
| lung secretory cell differentiation |
| commissural neuron axon guidance |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| lung epithelial cell differentiation |
| lung cell differentiation |
| central nervous system projection neuron axonogenesis |
| salivary gland morphogenesis |
| lung epithelium development |
| salivary gland development |
| regulation of mesenchymal cell proliferation |
| negative regulation of animal organ morphogenesis |
| central nervous system neuron axonogenesis |
| regulation of pri-miRNA transcription by RNA polymerase II |
| exocrine system development |
| neural nucleus development |
| central nervous system neuron development |
| chondrocyte differentiation |
| gland morphogenesis |
| negative regulation of epithelial cell proliferation |
| fibrillar center |
| tube formation |
| hindbrain development |
| lung development |
| glial cell differentiation |
| cartilage development |
| respiratory tube development |
| central nervous system neuron differentiation |
| respiratory system development |
| DNA replication |
| gliogenesis |
| connective tissue development |
| regulation of animal organ morphogenesis |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| regulation of epithelial cell proliferation |
| axonogenesis |
| forebrain development |
| axon development |
| gland development |
| cell morphogenesis involved in neuron differentiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| skeletal system development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| tube morphogenesis |
| neuron projection development |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| response to bacterium |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| negative regulation of developmental process |
| animal organ morphogenesis |
| central nervous system development |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NN-Diethyl-meta-toluamide 100μM R05 exp237 | -1.95 |
| Clomiphene 4.4μM R02 exp68 | -1.89 |
| A-395N 10μM R05 exp219 | -1.75 |
| UNC2400 2μM R03 exp156 | -1.72 |
| Benzoate 20000μM R08 exp456 | -1.71 |
| Q15 2.7μM R02 exp79 | 2.4 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14692
- Expression level (log2 read counts): 1.15
Expression Distribution
NFIB Expression in NALM6 Cells: 1.15
