NFKBID
Gene Information
- Official Symbol: NFKBID
- Official Name: NFKB inhibitor delta
- Aliases and Previous Symbols: N/A
- Entrez ID: 84807
- UniProt: Q8NI38
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Ank 2 |
| Ank |
GO Terms
| positive regulation of thymocyte apoptotic process |
| positive regulation of T-helper 17 cell differentiation |
| negative regulation of T cell differentiation in thymus |
| positive regulation of T-helper 17 type immune response |
| regulation of thymocyte apoptotic process |
| positive regulation of T cell apoptotic process |
| regulation of T-helper 17 cell differentiation |
| positive regulation of lymphocyte apoptotic process |
| regulation of T-helper 17 type immune response |
| positive regulation of T-helper cell differentiation |
| regulation of T cell differentiation in thymus |
| positive regulation of leukocyte apoptotic process |
| NF-kappaB binding |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of T cell apoptotic process |
| regulation of T-helper cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of T cell differentiation |
| negative regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of lymphocyte apoptotic process |
| negative regulation of lymphocyte differentiation |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| negative regulation of NF-kappaB transcription factor activity |
| positive regulation of T cell differentiation |
| regulation of leukocyte apoptotic process |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of leukocyte differentiation |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| regulation of adaptive immune response |
| negative regulation of DNA-binding transcription factor activity |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| T cell receptor signaling pathway |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of immune effector process |
| immune response-regulating cell surface receptor signaling pathway |
| inflammatory response |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of cell adhesion |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| positive regulation of immune response |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.484 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7706
- Expression level (log2 read counts): 3.27
Expression Distribution
NFKBID Expression in NALM6 Cells: 3.27
