NFKBIE

Entrez Summary: N/A
UniProt Summary: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

D-serine transport
serine transport
D-amino acid transport
cytoplasmic sequestering of transcription factor
cytoplasmic sequestering of protein
neutral amino acid transport
maintenance of protein location
amino acid transport
fibrillar center
drug transport
negative regulation of DNA-binding transcription factor activity
maintenance of location
organic acid transport
carboxylic acid transport
regulation of DNA-binding transcription factor activity
organic anion transport
anion transport
perinuclear region of cytoplasm
cation transport
Golgi apparatus
response to drug
negative regulation of molecular function
ion transport
nitrogen compound transport