NKX2-3

Entrez Summary: This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010].
UniProt Summary: Transcription factor. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

post-embryonic digestive tract morphogenesis
plasma cell differentiation
mucosal-associated lymphoid tissue development
Peyers patch development
post-embryonic animal morphogenesis
lymph node development
mature B cell differentiation involved in immune response
mature B cell differentiation
macrophage differentiation
spleen development
CD4-positive, alpha-beta T cell differentiation
CD4-positive, alpha-beta T cell activation
B cell activation involved in immune response
digestive tract morphogenesis
alpha-beta T cell differentiation
alpha-beta T cell activation
leukocyte homeostasis
triglyceride metabolic process
odontogenesis of dentin-containing tooth
post-embryonic development
acylglycerol metabolic process
gland morphogenesis
neutral lipid metabolic process
B cell differentiation
lymphocyte activation involved in immune response
myeloid leukocyte differentiation
odontogenesis
digestive tract development
T cell differentiation
digestive system development
B cell activation
homeostasis of number of cells
myeloid cell differentiation
T cell activation
lymphocyte differentiation
leukocyte differentiation
leukocyte migration
glycerolipid metabolic process
lymphocyte activation
gland development