NKX3-1
Gene Information
- Official Symbol: NKX3-1
- Official Name: NK3 homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4824
- UniProt: Q99801
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| MADS box domain binding |
| regulation of androgen secretion |
| positive regulation of androgen secretion |
| negative regulation of estrogen receptor binding |
| regulation of estrogen receptor binding |
| epithelial cell proliferation involved in salivary gland morphogenesis |
| estrogen receptor activity |
| negative regulation of epithelial cell proliferation involved in prostate gland development |
| negative regulation of insulin-like growth factor receptor signaling pathway |
| dorsal aorta development |
| branching involved in prostate gland morphogenesis |
| regulation of epithelial cell proliferation involved in prostate gland development |
| positive regulation of steroid hormone secretion |
| negative regulation of receptor binding |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| mitotic cell cycle arrest |
| site of DNA damage |
| regulation of steroid hormone secretion |
| prostate gland epithelium morphogenesis |
| regulation of insulin-like growth factor receptor signaling pathway |
| regulation of receptor binding |
| prostate gland morphogenesis |
| pharyngeal system development |
| salivary gland morphogenesis |
| salivary gland development |
| androgen receptor signaling pathway |
| response to testosterone |
| protein kinase B signaling |
| prostate gland development |
| exocrine system development |
| estrogen receptor binding |
| regulation of endocrine process |
| nuclear receptor activity |
| aorta development |
| protein self-association |
| negative regulation of reproductive process |
| positive regulation of intrinsic apoptotic signaling pathway |
| positive regulation of lipid transport |
| somitogenesis |
| intracellular steroid hormone receptor signaling pathway |
| transcription regulatory region sequence-specific DNA binding |
| positive regulation of lipid localization |
| somite development |
| metanephros development |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| artery development |
| positive regulation of cell division |
| epithelial cell proliferation |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| segmentation |
| gland morphogenesis |
| positive regulation of response to DNA damage stimulus |
| negative regulation of protein binding |
| regulation of lipid transport |
| histone deacetylase binding |
| regulation of phosphatidylinositol 3-kinase signaling |
| steroid hormone mediated signaling pathway |
| negative regulation of epithelial cell proliferation |
| positive regulation of hormone secretion |
| branching morphogenesis of an epithelial tube |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| male gonad development |
| development of primary male sexual characteristics |
| regulation of lipid localization |
| cell cycle arrest |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of mitotic cell cycle |
| male sex differentiation |
| morphogenesis of a branching epithelium |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of reproductive process |
| intracellular receptor signaling pathway |
| morphogenesis of a branching structure |
| regulation of cell division |
| hormone-mediated signaling pathway |
| negative regulation of binding |
| positive regulation of endopeptidase activity |
| cellular response to interleukin-1 |
| positive regulation of apoptotic signaling pathway |
| cellular response to hypoxia |
| cellular response to steroid hormone stimulus |
| positive regulation of peptidase activity |
| response to ketone |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| gonad development |
| cellular response to oxygen levels |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| development of primary sexual characteristics |
| anterior/posterior pattern specification |
| regulation of response to DNA damage stimulus |
| transcription regulatory region DNA binding |
| regulation of protein binding |
| cellular response to tumor necrosis factor |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| sex differentiation |
| regulation of hormone secretion |
| kidney development |
| renal system development |
| negative regulation of mitotic cell cycle |
| epithelial tube morphogenesis |
| urogenital system development |
| response to steroid hormone |
| transcription factor binding |
| regionalization |
| regulation of epithelial cell proliferation |
| response to hypoxia |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| positive regulation of cell cycle |
| regulation of binding |
| response to oxygen levels |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| cellular response to drug |
| gland development |
| regulation of endopeptidase activity |
| sequence-specific DNA binding |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| morphogenesis of an epithelium |
| positive regulation of secretion |
| pattern specification process |
| regulation of peptidase activity |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| cell population proliferation |
| tissue morphogenesis |
| negative regulation of cell cycle |
| regulation of system process |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of secretion |
| tube development |
| response to lipid |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| positive regulation of transport |
| cell cycle process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| positive regulation of phosphorylation |
| response to cytokine |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 2μM R00 exp16 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5367
- Expression level (log2 read counts): -1.49
Expression Distribution
NKX3-1 Expression in NALM6 Cells: -1.49
