NKX6-2 [The Human Chemical-Genetic Interaction Map Project]

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======= NKX6-2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX6-2
  * **<color #00a2e8>Official Name</color>**: NK6 homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84504|84504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C056|Q9C056]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX6-2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX6-2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'- (A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. {ECO:0000250|UniProtKB:D3Z4R4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification|
|regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification|
|positive regulation of cell fate commitment|
|ventral spinal cord interneuron specification|
|cell fate specification involved in pattern specification|
|negative regulation of cell fate commitment|
|spinal cord motor neuron cell fate specification|
|ventral spinal cord interneuron fate commitment|
|cell fate commitment involved in pattern specification|
|regulation of transcription involved in cell fate commitment|
|ventral spinal cord interneuron differentiation|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|negative regulation of glial cell differentiation|
|regulation of cell fate commitment|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|endocrine pancreas development|
|negative regulation of gliogenesis|
|regulation of myelination|
|oligodendrocyte development|
|positive regulation of glial cell differentiation|
|ventral spinal cord development|
|neuromuscular process controlling balance|
|cell differentiation in spinal cord|
|neuron fate commitment|
|regulation of glial cell differentiation|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|pancreas development|
|dorsal/ventral pattern formation|
|cell fate specification|
|myelination|
|spinal cord development|
|glial cell development|
|neuromuscular process|
|axon ensheathment|
|ensheathment of neurons|
|regulation of gliogenesis|
|endocrine system development|
|glial cell differentiation|
|central nervous system neuron differentiation|
|gliogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|regionalization|
|negative regulation of cell development|
|sequence-specific DNA binding|
|pattern specification process|
|positive regulation of neurogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of nervous system development|
|positive regulation of cell development|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17700
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX6-2 Expression in NALM6 Cells: -1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>