NKX6-2
Gene Information
- Official Symbol: NKX6-2
- Official Name: NK6 homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 84504
- UniProt: Q9C056
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'- (A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. {ECO:0000250|UniProtKB:D3Z4R4}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification |
| regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification |
| positive regulation of cell fate commitment |
| ventral spinal cord interneuron specification |
| cell fate specification involved in pattern specification |
| negative regulation of cell fate commitment |
| spinal cord motor neuron cell fate specification |
| ventral spinal cord interneuron fate commitment |
| cell fate commitment involved in pattern specification |
| regulation of transcription involved in cell fate commitment |
| ventral spinal cord interneuron differentiation |
| central nervous system myelination |
| axon ensheathment in central nervous system |
| spinal cord dorsal/ventral patterning |
| spinal cord patterning |
| negative regulation of glial cell differentiation |
| regulation of cell fate commitment |
| neuron fate specification |
| spinal cord motor neuron differentiation |
| endocrine pancreas development |
| negative regulation of gliogenesis |
| regulation of myelination |
| oligodendrocyte development |
| positive regulation of glial cell differentiation |
| ventral spinal cord development |
| neuromuscular process controlling balance |
| cell differentiation in spinal cord |
| neuron fate commitment |
| regulation of glial cell differentiation |
| oligodendrocyte differentiation |
| positive regulation of gliogenesis |
| pancreas development |
| dorsal/ventral pattern formation |
| cell fate specification |
| myelination |
| spinal cord development |
| glial cell development |
| neuromuscular process |
| axon ensheathment |
| ensheathment of neurons |
| regulation of gliogenesis |
| endocrine system development |
| glial cell differentiation |
| central nervous system neuron differentiation |
| gliogenesis |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| regionalization |
| negative regulation of cell development |
| sequence-specific DNA binding |
| pattern specification process |
| positive regulation of neurogenesis |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of nervous system development |
| positive regulation of cell development |
| DNA-binding transcription factor activity |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| negative regulation of transcription by RNA polymerase II |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| central nervous system development |
| neuron differentiation |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 2μM R00 exp16 | -1.98 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17700
- Expression level (log2 read counts): -1.69
Expression Distribution
NKX6-2 Expression in NALM6 Cells: -1.69
