NLE1 [The Human Chemical-Genetic Interaction Map Project]

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======= NLE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLE1
  * **<color #00a2e8>Official Name</color>**: notchless homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54475|54475]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVX2|Q9NVX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620924|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|NLE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hematopoietic stem cell homeostasis|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|inner cell mass cell differentiation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|ribosomal large subunit assembly|
|blastocyst formation|
|somitogenesis|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|somite development|
|negative regulation of cysteine-type endopeptidase activity|
|segmentation|
|blastocyst development|
|Notch signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|homeostasis of number of cells|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|anterior/posterior pattern specification|
|negative regulation of apoptotic signaling pathway|
|ribonucleoprotein complex assembly|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|negative regulation of peptidase activity|
|kidney development|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|ribosome biogenesis|
|negative regulation of mitotic cell cycle|
|urogenital system development|
|regionalization|
|negative regulation of proteolysis|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|pattern specification process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|skeletal system development|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of proteolysis|
|organelle assembly|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.03|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.77|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.73|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 537/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|22/28|
|bone|20/26|
|breast|24/33|
|central nervous system|38/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|16/21|
|liver|12/20|
|lung|51/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|20/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 873
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLE1 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>