NLE1

Gene Information

Official Symbol: NLE1
Official Name: notchless homolog 1
Aliases and Previous Symbols: N/A
Entrez ID: 54475
UniProt: Q9NVX2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 537/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	16/28
blood	22/28
bone	20/26
breast	24/33
central nervous system	38/56
cervix	4/4
colorectal	13/17
esophagus	13/13
fibroblast	1/1
gastric	10/16
kidney	16/21
liver	12/20
lung	51/75
lymphocyte	14/16
ovary	21/26
pancreas	19/24
peripheral nervous system	13/16
plasma cell	13/15
prostate	0/1
skin	18/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	16/22
urinary tract	20/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 873
Expression level (log2 read counts): 5.7

Expression Distribution

Screen	Score
Rotenone 20μM R00 exp34	-2.03
Aminopterin 0.005μM R07 exp335	-1.77
Tanespimycin 14μM R08 exp527	-1.73
LB-100 2μM R05 exp210	1.76

WD40
NLE

hematopoietic stem cell homeostasis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
inner cell mass cell differentiation
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ribosomal large subunit assembly
blastocyst formation
somitogenesis
ribosome assembly
ribosomal large subunit biogenesis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
somite development
negative regulation of cysteine-type endopeptidase activity
segmentation
blastocyst development
Notch signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
homeostasis of number of cells
regulation of cysteine-type endopeptidase activity involved in apoptotic process
anterior/posterior pattern specification
negative regulation of apoptotic signaling pathway
ribonucleoprotein complex assembly
skeletal system morphogenesis
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
ribonucleoprotein complex subunit organization
negative regulation of peptidase activity
kidney development
regulation of canonical Wnt signaling pathway
renal system development
ribosome biogenesis
negative regulation of mitotic cell cycle
urogenital system development
regionalization
negative regulation of proteolysis
regulation of Wnt signaling pathway
in utero embryonic development
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
pattern specification process