NLGN1

Gene Information

Official Symbol: NLGN1
Official Name: neuroligin 1
Aliases and Previous Symbols: N/A
Entrez ID: 22871
UniProt: Q8N2Q7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008].
UniProt Summary: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. {ECO:0000250|UniProtKB:Q99K10}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14358
Expression level (log2 read counts): -3.59

Expression Distribution

Abhydrolase 3
COesterase

positive regulation of presynaptic active zone assembly
regulation of presynaptic active zone assembly
positive regulation of presynapse assembly
cytoskeletal matrix organization at active zone
neurexin clustering involved in presynaptic membrane assembly
retrograde trans-synaptic signaling by trans-synaptic protein complex
positive regulation of circadian sleep/wake cycle, wakefulness
terminal button organization
NMDA glutamate receptor clustering
synaptic vesicle targeting
regulation of circadian sleep/wake cycle, wakefulness
glutamate receptor clustering
AMPA glutamate receptor clustering
positive regulation of synaptic vesicle clustering
postsynaptic density protein 95 clustering
asymmetric, glutamatergic, excitatory synapse
neuronal signal transduction
spanning component of membrane
positive regulation of synaptic vesicle endocytosis
negative regulation of dendritic spine morphogenesis
retrograde trans-synaptic signaling
neurotransmitter-gated ion channel clustering
synaptic vesicle clustering
trans-synaptic signaling by trans-synaptic complex
positive regulation of synaptic vesicle recycling
postsynaptic specialization assembly
positive regulation of synaptic vesicle exocytosis
regulation of synaptic vesicle clustering
positive regulation of protein localization to synapse
presynaptic membrane assembly
NMDA selective glutamate receptor complex
neuron projection arborization
presynaptic membrane organization
postsynaptic membrane assembly
positive regulation of synaptic transmission, GABAergic
neurexin family protein binding
regulation of respiratory gaseous exchange by nervous system process
negative regulation of dendritic spine development
excitatory synapse assembly
positive regulation of ruffle assembly