NLRC5

Gene Information

Official Symbol: NLRC5
Official Name: NLR family CARD domain containing 5
Aliases and Previous Symbols: N/A
Entrez ID: 84166
UniProt: Q86WI3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3261
Expression level (log2 read counts): 6.27

Expression Distribution

NACHT
LRR 4

positive regulation of MHC class I biosynthetic process
positive regulation of response to interferon-gamma
positive regulation of interferon-gamma-mediated signaling pathway
regulation of MHC class I biosynthetic process
positive regulation of type I interferon-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
regulation of response to interferon-gamma
regulation of type I interferon-mediated signaling pathway
negative regulation of type I interferon production
positive regulation of cytokine-mediated signaling pathway
negative regulation of innate immune response
positive regulation of response to cytokine stimulus
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
negative regulation of NF-kappaB transcription factor activity
negative regulation of response to biotic stimulus
regulation of type I interferon production
negative regulation of immune response
negative regulation of DNA-binding transcription factor activity
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
defense response to virus
negative regulation of defense response
negative regulation of multi-organism process
negative regulation of cytokine production
response to virus
positive regulation of innate immune response
positive regulation of response to biotic stimulus
negative regulation of response to external stimulus
regulation of DNA-binding transcription factor activity
negative regulation of immune system process
regulation of innate immune response
positive regulation of defense response
centrosome
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
response to bacterium