NME2
Gene Information
- Official Symbol: NME2
- Official Name: NME/NM23 nucleoside diphosphate kinase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4831
- UniProt: P22392
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}.
Pfam Domains GO Terms
Pfam Domains
| NDK |
GO Terms
| protein histidine kinase activity |
| peptidyl-histidine phosphorylation |
| G-quadruplex DNA binding |
| UTP biosynthetic process |
| intermediate filament binding |
| peptidyl-histidine modification |
| GTP biosynthetic process |
| UTP metabolic process |
| CTP metabolic process |
| guanosine-containing compound biosynthetic process |
| CTP biosynthetic process |
| pyrimidine ribonucleoside triphosphate biosynthetic process |
| positive regulation of keratinocyte differentiation |
| pyrimidine ribonucleoside triphosphate metabolic process |
| nucleoside diphosphate kinase activity |
| pyrimidine nucleoside triphosphate biosynthetic process |
| pyrimidine ribonucleotide biosynthetic process |
| ribonucleoside biosynthetic process |
| purine ribonucleoside biosynthetic process |
| pyrimidine nucleoside triphosphate metabolic process |
| purine nucleoside biosynthetic process |
| fatty acid binding |
| pyrimidine ribonucleotide metabolic process |
| positive regulation of epidermal cell differentiation |
| GTP metabolic process |
| nucleobase-containing small molecule interconversion |
| response to growth hormone |
| cell periphery |
| positive regulation of epidermis development |
| nucleoside biosynthetic process |
| guanosine-containing compound metabolic process |
| regulation of keratinocyte differentiation |
| glycosyl compound biosynthetic process |
| purine ribonucleoside triphosphate biosynthetic process |
| purine nucleoside triphosphate biosynthetic process |
| negative regulation of myeloid leukocyte differentiation |
| pyrimidine nucleotide biosynthetic process |
| ribonucleoside triphosphate biosynthetic process |
| cellular response to fatty acid |
| pyrimidine-containing compound biosynthetic process |
| positive regulation of epithelial cell differentiation |
| purine ribonucleoside triphosphate metabolic process |
| nucleoside diphosphate phosphorylation |
| purine ribonucleoside metabolic process |
| regulation of epidermal cell differentiation |
| nucleotide phosphorylation |
| pyrimidine nucleotide metabolic process |
| nucleoside triphosphate biosynthetic process |
| purine nucleoside metabolic process |
| ribonucleoside triphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| GDP binding |
| ribonucleoside metabolic process |
| negative regulation of myeloid cell differentiation |
| cellular response to carbohydrate stimulus |
| nucleoside diphosphate metabolic process |
| response to fatty acid |
| regulation of epidermis development |
| cellular glucose homeostasis |
| nucleoside triphosphate metabolic process |
| ruffle |
| integrin-mediated signaling pathway |
| negative regulation of leukocyte differentiation |
| mitochondrial membrane |
| pyrimidine-containing compound metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| regulation of myeloid leukocyte differentiation |
| secretory granule lumen |
| intermediate filament |
| ficolin-1-rich granule lumen |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| glycosyl compound metabolic process |
| negative regulation of hemopoiesis |
| response to glucose |
| regulation of epithelial cell differentiation |
| response to hexose |
| cAMP-mediated signaling |
| response to monosaccharide |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| response to carbohydrate |
| cyclic-nucleotide-mediated signaling |
| lamellipodium |
| glucose homeostasis |
| carbohydrate homeostasis |
| positive regulation of epithelial cell proliferation |
| protein autophosphorylation |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| cellular response to acid chemical |
| regulation of myeloid cell differentiation |
| cellular response to oxidative stress |
| nucleotide biosynthetic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| nucleoside phosphate biosynthetic process |
| regulation of leukocyte differentiation |
| positive regulation of neuron projection development |
| transcription coactivator activity |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| regulation of epithelial cell proliferation |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| response to acid chemical |
| enzyme binding |
| protein serine/threonine kinase activity |
| purine-containing compound metabolic process |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| response to oxidative stress |
| response to peptide hormone |
| focal adhesion |
| negative regulation of immune system process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| regulation of hemopoiesis |
| positive regulation of neurogenesis |
| response to peptide |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| cellular response to lipid |
| myeloid cell activation involved in immune response |
| positive regulation of nervous system development |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| positive regulation of cell development |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulated exocytosis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cellular chemical homeostasis |
| leukocyte mediated immunity |
| exocytosis |
| regulation of neurogenesis |
| response to lipid |
| peptidyl-amino acid modification |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| negative regulation of cell death |
| response to organonitrogen compound |
| secretion by cell |
| carbohydrate derivative metabolic process |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| nucleobase-containing compound biosynthetic process |
| chemical homeostasis |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| DNA binding |
| response to endogenous stimulus |
| ATP binding |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tubastatin-A 2.5μM R07 exp417 | -1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15125
- Expression level (log2 read counts): 6.34
Expression Distribution
NME2 Expression in NALM6 Cells: 6.34
