NMU [The Human Chemical-Genetic Interaction Map Project]

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======= NMU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NMU
  * **<color #00a2e8>Official Name</color>**: neuromedin U
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10874|10874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48645|P48645]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NMU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NMU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NMU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 2 neuromedin U receptor binding|
|neuromedin U receptor binding|
|regulation of stomach fundus smooth muscle contraction|
|positive regulation of blood pressure in other organism|
|positive regulation of stomach fundus smooth muscle contraction|
|modulation of blood pressure in other organism|
|type 1 neuromedin U receptor binding|
|regulation of gastric emptying|
|negative regulation of gastric emptying|
|negative regulation of eating behavior|
|positive regulation of prolactin secretion|
|regulation of grooming behavior|
|regulation of gastric motility|
|positive regulation of gastro-intestinal system smooth muscle contraction|
|regulation of gastro-intestinal system smooth muscle contraction|
|regulation of eating behavior|
|negative regulation of gastric acid secretion|
|positive regulation of sensory perception of pain|
|gastric acid secretion|
|negative regulation of feeding behavior|
|positive regulation of heat generation|
|regulation of gastric acid secretion|
|regulation of heat generation|
|negative regulation of behavior|
|regulation of circadian sleep/wake cycle, sleep|
|negative regulation of digestive system process|
|regulation of circadian sleep/wake cycle|
|positive regulation of heart rate|
|photoperiodism|
|regulation of feeding behavior|
|eating behavior|
|temperature homeostasis|
|positive regulation of smooth muscle contraction|
|energy homeostasis|
|positive regulation of blood pressure|
|positive regulation of heart contraction|
|regulation of sensory perception of pain|
|regulation of digestive system process|
|regulation of sensory perception|
|positive regulation of muscle contraction|
|terminal bouton|
|regulation of smooth muscle contraction|
|positive regulation of nervous system process|
|positive regulation of blood circulation|
|regulation of behavior|
|digestive system process|
|sensory perception of pain|
|acid secretion|
|feeding behavior|
|positive regulation of peptide hormone secretion|
|regulation of heart rate|
|neuropeptide signaling pathway|
|digestion|
|regulation of circadian rhythm|
|positive regulation of hormone secretion|
|regulation of nervous system process|
|positive regulation of synaptic transmission|
|regulation of muscle contraction|
|regulation of blood pressure|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|response to light stimulus|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|sensory perception|
|positive regulation of transport|
|regulation of protein localization|
|chemical homeostasis|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NMU Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>