NMU
Gene Information
- Official Symbol: NMU
- Official Name: neuromedin U
- Aliases and Previous Symbols: N/A
- Entrez ID: 10874
- UniProt: P48645
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Pfam Domains GO Terms
Pfam Domains
| NMU |
GO Terms
| type 2 neuromedin U receptor binding |
| neuromedin U receptor binding |
| regulation of stomach fundus smooth muscle contraction |
| positive regulation of blood pressure in other organism |
| positive regulation of stomach fundus smooth muscle contraction |
| modulation of blood pressure in other organism |
| type 1 neuromedin U receptor binding |
| regulation of gastric emptying |
| negative regulation of gastric emptying |
| negative regulation of eating behavior |
| positive regulation of prolactin secretion |
| regulation of grooming behavior |
| regulation of gastric motility |
| positive regulation of gastro-intestinal system smooth muscle contraction |
| regulation of gastro-intestinal system smooth muscle contraction |
| regulation of eating behavior |
| negative regulation of gastric acid secretion |
| positive regulation of sensory perception of pain |
| gastric acid secretion |
| negative regulation of feeding behavior |
| positive regulation of heat generation |
| regulation of gastric acid secretion |
| regulation of heat generation |
| negative regulation of behavior |
| regulation of circadian sleep/wake cycle, sleep |
| negative regulation of digestive system process |
| regulation of circadian sleep/wake cycle |
| positive regulation of heart rate |
| photoperiodism |
| regulation of feeding behavior |
| eating behavior |
| temperature homeostasis |
| positive regulation of smooth muscle contraction |
| energy homeostasis |
| positive regulation of blood pressure |
| positive regulation of heart contraction |
| regulation of sensory perception of pain |
| regulation of digestive system process |
| regulation of sensory perception |
| positive regulation of muscle contraction |
| terminal bouton |
| regulation of smooth muscle contraction |
| positive regulation of nervous system process |
| positive regulation of blood circulation |
| regulation of behavior |
| digestive system process |
| sensory perception of pain |
| acid secretion |
| feeding behavior |
| positive regulation of peptide hormone secretion |
| regulation of heart rate |
| neuropeptide signaling pathway |
| digestion |
| regulation of circadian rhythm |
| positive regulation of hormone secretion |
| regulation of nervous system process |
| positive regulation of synaptic transmission |
| regulation of muscle contraction |
| regulation of blood pressure |
| regulation of peptide hormone secretion |
| negative regulation of secretion |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| response to light stimulus |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| signaling receptor binding |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of hormone levels |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| cellular homeostasis |
| sensory perception |
| positive regulation of transport |
| regulation of protein localization |
| chemical homeostasis |
| secretion |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| homeostatic process |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pomalidomide 20μM R07 exp391 | -2.01 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15774
- Expression level (log2 read counts): -5.01
Expression Distribution
NMU Expression in NALM6 Cells: -5.01
