NOC3L [The Human Chemical-Genetic Interaction Map Project]

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======= NOC3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOC3L
  * **<color #00a2e8>Official Name</color>**: NOC3 like DNA replication regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64318|64318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTT2|Q8WTT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOC3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOC3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for adipogenesis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOC3p|
|CBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fat cell differentiation|
|chromatin binding|
|nuclear speck|
|nucleolus|
|mitochondrion|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.65|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.58|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.48|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.42|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.28|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.17|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.97|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.93|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.85|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.83|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.82|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.8|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.73|
|[[:results:exp539|42°C R08 exp539]]|-1.71|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.7|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.75|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.76|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.81|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.88|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.91|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.41|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.42|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.46|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|19/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOC3L Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>