NOC3L [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: NOC3L
Official Name: NOC3 like DNA replication regulator
Aliases and Previous Symbols: N/A
Entrez ID: 64318
UniProt: Q8WTT2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be required for adipogenesis. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04μM R07 exp418	-2.65
Pifithrin-alpha 20μM R07 exp390	-2.58
Rapamycin 0.001μM R08 exp429	-2.48
Isoniazid 100μM R08 exp494	-2.42
MK-1775 0.32μM R02 exp75	-2.28
CB-5083 0.4μM R08 exp468	-2.2
Thimerosal 0.85μM R08 exp529	-2.17
Hippuristanol 0.12μM R08 exp488	-1.97
BRD2 inhibitor II 20μM R07 exp341	-1.93
Arsenic trioxide 60μM R08 exp449	-1.85
FK-506 5μM R07 exp358	-1.83
Citral 75μM R06 exp275	-1.82
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.81
GSK-J4 1.5μM R08 exp441	-1.8
FTY720 3μM R08 exp483	-1.73
42°C R08 exp539	-1.71
GSK461364A 0.005μM R03 exp125	-1.7
Bisphenol F 50μM R08 exp457	1.75
Calcipotriol 5μM R08 exp464	1.76
Docetaxel 0.002μM R01 exp45	1.81
CCCP 0.1μM R00 exp10	1.88
Palbociclib 1μM R07 exp382	1.91
MS023 2μM R03 exp134	2.41
Nicotinamide 2000μM R01 exp50	2.42
Vinblastine 0.002μM R01 exp60	2.46
Apcin 25μM plus proTAME 2μM R04 exp177	2.87

Global Fraction of Cell Lines Where Essential: 717/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	19/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1432
Expression level (log2 read counts): 6.11

Expression Distribution

Last modified: 2026/01/07 22:36
by 127.0.0.1