NOS3

Entrez Summary: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

muscle hyperplasia
smooth muscle hyperplasia
negative regulation of muscle hyperplasia
regulation of muscle hyperplasia
nitric-oxide synthase activity
smooth muscle adaptation
tetrahydrobiopterin binding
cadmium ion binding
regulation of systemic arterial blood pressure by endothelin
NADPH-hemoprotein reductase activity
regulation of the force of heart contraction by chemical signal
arginine binding
ovulation from ovarian follicle
positive regulation of guanylate cyclase activity
arginine catabolic process
negative regulation of muscle adaptation
regulation of guanylate cyclase activity
removal of superoxide radicals
nitric oxide biosynthetic process
cellular response to superoxide
cellular response to oxygen radical
FMN binding
pulmonary valve morphogenesis
arginine metabolic process
nitric oxide metabolic process
response to superoxide
ovulation
response to oxygen radical
negative regulation of platelet activation
nitric oxide mediated signal transduction
reactive nitrogen species metabolic process
pulmonary valve development
positive regulation of nucleotide biosynthetic process
positive regulation of cyclase activity
positive regulation of purine nucleotide biosynthetic process
positive regulation of lyase activity
reactive oxygen species biosynthetic process
glutamine family amino acid catabolic process
regulation of the force of heart contraction
negative regulation of biomineralization