NOTCH2NL [The Human Chemical-Genetic Interaction Map Project]

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======= NOTCH2NL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOTCH2NLA
  * **<color #00a2e8>Official Name</color>**: notch 2 N-terminal like A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388677|388677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3S9|Q7Z3S9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOTCH2NL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOTCH2NL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function in the Notch signaling pathway and regulate neutrophil differentiation. {ECO:0000269|PubMed:14673143}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Notch binding|
|positive regulation of Notch signaling pathway|
|regulation of Notch signaling pathway|
|cerebral cortex development|
|Notch signaling pathway|
|pallium development|
|telencephalon development|
|forebrain development|
|calcium ion binding|
|brain development|
|head development|
|central nervous system development|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.31|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.18|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.01|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.86|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.73|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.71|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.77|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.78|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.8|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.9|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.11|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.19|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.19|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.35|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2444
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOTCH2NL Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>